Fibrinogen Assay

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Assay of fibrinogen in small blood samples.

T IS DIFFICULT to perform accurate fibrinogen assays on small samples of blood. A significant fraction of the plasma is lost when it is separated from the cells in 0.1or 0.2-mi. samples of blood and the plasma is diluted to a variable, usually undetermined, extent by the addition of anticoagulant. This can be minimized by using heparin dried in capillary tubes, but heparin interferes with subse...

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Quantitative Assay of Fibrinogen and Fibrinolytic Activity.

ECENT YEARS have brought increased appreciation of the importance of the role of fibrinolysis in the regulation of normal hemostasis and in the production of abnormal bleeding. The mechanisms by which active fibrinolysis is induced are far from clear, but it does seem likely that it can be brought about by shock,1 severe emotional stress,2 injection of adrenalin,2 anoxia3 and liberation of acti...

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Latex-bound antifibrinogen test for plasma fibrinogen assay.

The semiquantitative latex-bound antifibrinogen test (Fi test) can be modified to quantitate plasma fibrinogen. The test is rapid and simple and does not require complex apparatus. Although the Fi reagent reacts with early fibrinogen and fibrin breakdown products, the degree of interference is not marked and the test is sufficiently accurate to be of clinical value as a fibrinogen assay in pati...

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Harmonization of fibrinogen assay results: study within the framework of the Dutch project 'Calibration 2000'.

In a Dutch project for harmonization of fibrinogen assays, the commutability of potential calibrators for fibrinogen was assessed by means of a twin-study design, which is, in essence, a multicentre, split-patient sample, between-field-methods protocol. The study consisted of simultaneous analysis of fresh-frozen patient plasmas and three potential calibrators for fibrinogen by 48 Dutch laborat...

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This review of published studies was conducted to derive data on patients with congenital fibrinogen deficiency (CFD), including dosing of fibrinogen replacement therapy, outcome, and adverse events, either temporally related or distant to fibrinogen replacement, in order to assist clinicians in developing treatment plans for patients with CFD. A systematic review was performed of case reports ...

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ژورنال

عنوان ژورنال: Clinical Chemistry

سال: 1967

ISSN: 0009-9147,1530-8561

DOI: 10.1093/clinchem/13.11.1026